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| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Margarita Gasparyan | Win | 7-6 (7-5), 6-3 |
| Second Round | Johanna Larsson | Win | 6-2, 5-7, 6-4 |
| Third Round | Dominika Cibulkova | Loss | 6-3, 3-6, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | 4-6, 7-5, 6-4 |
| Third Round | Madison Keys | Loss | 6-2, 6-7 (3-7), 4-6 |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Loss | 4-6, 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Vera Zvonareva | Win | 7-5, 6-3 |
| Second Round | Claire Liu | Win | 3-6, 6-2, 6-4 |
| Third Round | Naomi Osaka | Win | 6-2, 6-4 |
| Fourth Round | Belinda Bencic | Win | 6-3, 7-6 (7-5) |
| Quarterfinals | Daria Kasatkina | Win | 6-3, 7-5 |
| Semifinals | Jelena Ostapenko | Win | 6-3, 6-3 |
| Final | Serena Williams | Win | 6-3, 6-3 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 24 - Jun. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominika Cibulkova | Win | 6-3, 6-3 |
| Third Round | Danielle Collins | Win | 6-1, 6-1 |
| Quarterfinals | Daria Kasatkina | Win | 6-1, 6-7 (3-7), 7-6 (7-3) |
| Semifinals | Caroline Wozniacki | Loss | 6-2, 6-7 (4-7), 4-6 |
| Mallorca Open | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Loss | 7-5, 2-6, 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Mona Barthel | Win | 6-2, 6-3 |
| Second Round | Ana Bogdan | Win | 6-2, 6-3 |
| Third Round | Kiki Bertens | Win | 7-6 (7-4), 7-6 (7-4) |
| Fourth Round | Caroline Garcia | Win | 6-2, 6-3 |
| Quarterfinals | Simona Halep | Loss | 7-6 (7-2), 3-6, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Zarina Diyas | Win | 6-2, 7-6 (8-6) |
| Second Round | Irina-Camelia Begu | Win | 3-6, 7-5, 7-5 |
| Third Round | Maria Sakkari | Win | 6-1, 6-1 |
| Quarterfinals | Elina Svitolina | Loss | 4-6, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Kvitova | Win | 6-3, 6-2 |
| Second Round | Anett Kontaveit | Loss | 0-6, 0-2 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Johanna Larsson | Win | 6-2, 6-2 |
| Third Round | Anastasia Pavlyuchenkova | Win | 6-4, 6-4 |
| Fourth Round | Yafan Wang | Win | 6-7 (1-7), 7-6 (7-5), 6-3 |
| Quarterfinals | Sloane Stephens | Loss | 1-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Makarova | Win | 3-6, 6-4, 6-2 |
| Third Round | Elena Vesnina | Win | 7-5, 6-2 |
| Fourth Round | Caroline Garcia | Win | 6-1, 6-1 |
| Quarterfinals | Daria Kasatkina | Loss | 0-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 24 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Barbora Strycova | Win | 6-2, 6-1 |
| Second Round | Sara Errani | Win | 6-4, 6-2 |
| Quarterfinals | Karolina Pliskova | Win | 6-4, 6-3 |
| Semifinals | Elina Svitolina | Loss | 3-6, 3-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Samantha Stosur | Win | 6-4, 6-1 |
| Third Round | Johanna Konta | Win | 1-6, 6-1, 6-3 |
| Quarterfinals | Caroline Wozniacki | Loss | 6-7 (4-7), 6-1, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 21 |
| Round | Opponent | W / L | Result |
| First Round | Anna-Lena Friedsam | Win | 6-0, 6-4 |
| Second Round | Donna Vekic | Win | 6-4, 6-1 |
| Third Round | Maria Sharapova | Win | 6-1, 6-3 |
| Fourth Round | Su-Wei Hsieh | Win | 4-6, 7-5, 6-2 |
| Quarterfinals | Madison Keys | Win | 6-1, 6-2 |
| Semifinals | Simona Halep | Loss | 3-6, 6-4, 7-9 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 7 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Lucie Safarova | Win | 6-7 (3-7), 7-6 (10-8), 6-2 |
| Second Round | Venus Williams | Win | 5-7, 6-3, 6-1 |
| Quarterfinals | Dominika Cibulkova | Win | 6-3, 6-1 |
| Semifinals | Camila Giorgi | Win | 6-2, 6-3 |
| Final | Ashleigh Barty | Win | 6-4, 6-4 |
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